Journal club presentation by A.Farokhi

Asymmetry of the temporal code for space by hippocampal place cells

Bryan C. Souza & Adriano B. L. Tort

Link to paper

Abstract

Hippocampal place cells convey spatial information through spike frequency (“rate coding”) and spike timing relative to the theta phase (“temporal coding”). Whether rate and temporal coding are due to independent or related mechanisms has been the subject of wide debate. Here we show that the spike timing of place cells couples to theta phase before major increases in fring rate, anticipating the animal’s entrance into the classical, rate-based place feld. In contrast, spikes rapidly decouple from theta as the animal leaves the place feld and fring rate decreases. Therefore, temporal coding has strong asymmetry around the place feld center. We further show that the dynamics of temporal coding along space evolves in three stages as the animal traverses the place feld: phase coupling, sharp precession and phase decoupling. These results suggest that independent mechanisms may govern rate and temporal coding.

 

About This Event

Start date11/22/2017 10:00
End date11/22/2017 12:00

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