Journal club presentation by M.Dehghani

Optogenetically induced spatiotemporal gamma oscillations and neuronal spiking activity in primate motor cortex

Yao Lu, Wilson Truccolo, Fabien B. Wagner, Carlos E. Vargas-Irwin, Ilker Ozden, Jonas B. Zimmermann

Link to paper


Transient gamma-band (40–80 Hz) spatiotemporal patterns are hypothesized to play important roles in cortical function. Here we report the direct observation of gamma oscillations as spatiotemporal waves induced by targeted optogenetic stimulation, recorded by intracortical multichannel extracellular techniques in macaque monkeys during their awake resting states. Microelectrode arrays integrating an optical fiber at their center were chronically implanted in primary motor (M1) and ventral premotor (PMv) cortices of two subjects. Targeted brain tissue was transduced with the red-shifted opsin C1V1(T/T). Constant (1-s square pulses) and ramp stimulation induced narrowband gamma oscillations during awake resting states. Recordings across 95 microelectrodes (4 × 4-mm array) enabled us to track the transient gamma spatiotemporal patterns manifested, e.g., as concentric expanding and spiral waves. Gamma oscillations were induced well beyond the light stimulation volume, via network interactions at distal electrode sites, depending on optical power. Despite stimulation-related modulation in spiking rates, neuronal spiking remained highly asynchronous during induced gamma oscillations. In one subject we examined stimulation effects during preparation and execution of a motor task and observed that movement execution largely attenuated optically induced gamma oscillations. Our findings demonstrate that, beyond previously reported induced gamma activity under periodic drive, a prolonged constant stimulus above a certain threshold may carry primate motor cortex network dynamics into gamma oscillations, likely via a Hopf bifurcation. More broadly, the experimental capability in combining microelectrode array recordings and optogenetic stimulation provides an important approach for probing spatiotemporal dynamics in primate cortical networks during various physiological and behavioral conditions.

About This Event

Start date11/29/2017 10:00
End date11/29/2017 12:00



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    In July, 2017 we held a one-day mini-symposium at IUST, for the interchange of scientific expertise and findings between different projects of the our lab and external collaborating teams. The lectures were organized in two panels: Invited talks (given by principle investigators cooperating with our lab) and Project presentations (delivered by PhD students). Topics ranging all the way from the dynamics of neural coding in primate brain to computational approaches in modeling the neural system were covered through these lectures. Importantly we had the honor to host Dr. Fatemeh Bakouie (Shahid Beheshti University), Dr. Zeinab Fazlali (IPM School of Cognitive Sciences), Prof. Dr. Shahriyar Gharibzadeh (Amirkabir University of Technology) and Dr. Marzieh Zare (IPM School of Computer Sciences), to present their ongoing research lines in the symposium.
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